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Symbol
Name
ID

Pitx3
paired-like homeodomain transcription factor 3
MGI:1100498

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Chorea	Intellectual disability	Reduced tendon reflexes
Disease(s) Associated with PITX3
cataract 11 multiple types

Mouse Phenotypes		nervous system phenotype	increased neuron apoptosis	abnormal midbrain morphology	abnormal substantia nigra pars compacta morphology	decreased substantia nigra size	abnormal dorsal striatum morphology	decreased dopaminergic neuron number	loss of dopaminergic neurons	increased neuron number
Availability	Mouse Genotype	nervous system phenotype	increased neuron apoptosis	abnormal midbrain morphology	abnormal substantia nigra pars compacta morphology	decreased substantia nigra size	abnormal dorsal striatum morphology	decreased dopaminergic neuron number	loss of dopaminergic neurons	increased neuron number
	Pitx3^ak/Pitx3^ak
	Pitx3^eyl/Pitx3^eyl
	Pitx3^tm1.1Jdr/Pitx3^tm1.1Jdr
	Pitx3^tm1Mli/Pitx3^tm1Mli
	Pitx3^tm2Mli/Pitx3^tm2Mli	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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